(Lys²²)-Amyloid β-Protein (1-40)

Catalog No：GA20244-1mg CAS No.：302905-01-7 MDLNo： Brand:Glpbio purity： 特性： Purpose:The Italian mutation of β-amyloid 1-40 (E22K) aggregates more rapidly than the wild-type sequence 1-40. It showed increased neurotoxicity, which (according to a solid-phase NMR-study of Masuda et al.) may be due to the salt bridge formed between Lys²² and Asp²³ in the minor conformer. As the Arctic, Flemish, and Dutch mutants, the Italian mutant is degraded considerably more slowly than wild-type Aβ by neprilysin.Soluble in DMSO