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Prexasertib Mesylate Hydrate

Glpbio
Catalog No:GC36967-25mg CAS No.:1234015-57-6 MDLNo: Brand:Glpbio purity: 特性: Purpose:Prexasertib Mesylate Hydrate (LY2606368 Mesylate Hydrate) 是一种有效、选择性、 ATP 竞争性的 CHK1 和 CHK2 抑制剂,对 CHK1 的 Ki 值为 0.9 nM,IC50 值 <1 nM,对 CHK2 的 IC50 值为 8 nM。Prexasertib Mesylate Hydrate 抑制 HT-29 细胞 CHK1 (S296) 和 CHK2 (S516) 的自身磷酸化。Prexasertib Mesylate Hydrate 具有高效抗肿瘤活性,在 HeLa 细胞中,消除 G2/M 检查点,EC50 值为 9 nM。Soluble in DMSO
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