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PROTAC Bcl2 degrader-1

Glpbio
Catalog No:GC38941-10mg CAS No.:2378801-85-3 MDLNo: Brand:Glpbio purity: 特性: Purpose:PROTAC Bcl2 degrader-1 (Compound C5) 是一种 PROTAC,通过将 E3 连接酶 cereblon 的配体 pomalidomide 引入到 Mcl-1/Bcl-2 的双重抑制剂 Nap-1,来有效、特异性地诱导 Bcl-2 (IC50,4.94 μM;DC50,3.0 μM) 和 Mcl-1 (IC50,11.81 μM) 的降解。DMSO: 25 mg/mL (26.54 mM)
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