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VU0467485

Glpbio
Catalog No:GC38957-5mg CAS No.:1451994-10-7 MDLNo: Brand:Glpbio purity: 特性: Purpose:VU0467485 (AZ13713945) 是一种有效的、选择性的、口服生物可利用的毒蕈碱乙酰胆碱受体 4 (M4) 正变构调节剂 (PAM)。VU0467485 (AZ13713945) 增强了 ACh 在 M4 的活性,在大鼠和人 M4 受体上的 EC50 分别为 26.6 nM 和 78.8 nM。VU0467485 (AZ13713945) 显示 M4 对人和大鼠 M1/2/3/5 的选择性。VU0467485 (AZ13713945) 显示中度至高度中枢神经系统渗透,并具有抗精神病样活性。Soluble in DMSO
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