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GNE-987

Glpbio

Catalog No：GC60883-1mg CAS No.： MDLNo：C56H67F2N9O8S2 Brand:Glpbio purity： 特性： Purpose:GNE-987是一种高活性的嵌合体BET降解剂。GNE-987显示皮摩尔细胞BRD4降解活性(在EOL-1AML细胞系中，DC50=0.03nM)。GNE-987与BRD4的BD1和BD2结合，具有低纳米摩尔亲和力(IC50分别为4.7和4.4nM)。它包含一个有效的BET结合剂/抑制剂、一个VHL结合片段和一个十个亚甲基间隔基部分。GNE-987用于PROTAC-Antibody偶联物(PAC)中。DMSO: 150 mg/mL (136.82 mM; Need ultrasonic)

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Product Overview

Product Name	GNE-987
MW	1096.31
MDL	C56H67F2N9O8S2
Storage condition	4°C, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

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