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SD-36

Glpbio
Catalog No:GC61270-25mg CAS No.: MDLNo:C59H62F2N9O12P Brand:Glpbio purity: 特性: Purpose:SD-36是一种有效的PROTACSTAT3降解剂(Kd=~50nM),与其他STAT成员相比具有很高的选择性。SD-36有效降解细胞中突变的STAT3蛋白,并抑制STAT3的转录活性(IC50=10nM)。SD-36发挥强大的抗肿瘤活性,并在小鼠肿瘤模型中实现了完整而持久的肿瘤消退。SD-36由STAT3抑制剂SI-109、linker和一个用于E3泛素连接酶的CRBN配体Lenalidomide类似物组成。DMSO: 150 mg/mL (129.52 mM; Need ultrasonic)
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Product Overview
Product Name SD-36
MW1158.15
MDLC59H62F2N9O12P
Storage condition-20°C, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
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