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Pactimibe

Glpbio

Catalog No：GC61631-50mg CAS No.：189198-30-9 MDLNo：C25H40N2O3 Brand:Glpbio purity： 特性： Purpose:Pactimibe(CS-505freebase)是一种ACAT1/2双重抑制剂，对于ACAT1的IC50值为4.9μM，对于ACAT2的IC50值为3.0μM。Pactimibe(CS-505freebase)抑制ACAT，其IC50值在肝细胞中是2.0μM，在巨噬细胞中是2.7μM，在THP-1细胞中是4.7μM。Pactimibe(CS-505freebase)非竞争性抑制oleoyl-CoA，Ki是5.6μM。此外，Pactimibe(CS-505freebase)明显抑制胆固醇酯的形成，IC50是6.7μM。Pactimibe(CS-505freebase)具有抗动脉粥样硬化的潜力，可降低血浆胆固醇的活性。DMSO: 200 mg/mL (480.08 mM; Need ultrasonic)

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Product Overview

Product Name	Pactimibe
CAS	189198-30-9
MW	416.6
MDL	C25H40N2O3
Storage condition	4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)