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LC-2

Glpbio
Catalog No:GC61766-1mg CAS No.:2502156-03-6 MDLNo:C59H71ClFN11O7S Brand:Glpbio purity: 特性: Purpose:LC-2是首创的内源性KRASG12C的PROTAC降解剂,DC50在0.25和0.76μM之间。LC-2是一种PROTAC,与MRTX849共价结合KRASG12C并招募E3连接酶VHL,诱导KRASG12C快速持续降解,导致纯合和杂合子KRASG12C细胞系MAPK信号的抑制。DMSO: 50 mg/mL (44.14 mM; ultrasonic and warming and heat to 80°C)
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Product Overview
Product Name LC-2
CAS2502156-03-6
MW1132.78
MDLC59H71ClFN11O7S
Storage conditionPowder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
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