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AMG-548 dihydrochloride

Glpbio

Catalog No：GC38518-10mg CAS No.： MDLNo： Brand:Glpbio purity： 特性： Purpose:AMG-548 dihydrochloride 是一种有效的，口服有效的，选择性 p38α 抑制剂 (Ki=0.5 nM)，对 p38β 略有选择性 (Ki=36 nM) 并且对 p38γ 和 p38δ 具有 1000 倍的选择性。AMG-548 dihydrochloride 也有效抑制全血 LPS 刺激的 TNFα (IC50=3 nM)。AMG-548 dihydrochloride 通过直接抑制酪蛋白激酶 1 (Casein kinase 1) 同种型 δ 和 ε 来抑制 Wnt 信号传导。Soluble in DMSO

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Product Overview

Product Name	AMG-548 dihydrochloride
Formula	C₂₉H₂₉Cl₂N₅O
MW	534.48
Storage condition	Store at -20°C

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