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Glpbio

(Lys²²)-Amyloid β-Protein (1-40)

产品编号:GA20244-1mg CAS No.:302905-01-7 品牌:Glpbio 等级: 特性: 用途:The Italian mutation of β-amyloid 1-40 (E22K) aggregates more rapidly than the wild-type sequence 1-40. It showed increased neurotoxicity, which (according to a solid-phase NMR-study of Masuda et al.) may be due to the salt bridge formed between Lys²² and Asp²³ in the minor conformer. As the Arctic, Flemish, and Dutch mutants, the Italian mutant is degraded considerably more slowly than wild-type Aβ by neprilysin.Soluble in DMSO
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